Scientist Protein Engineering - Charleroi, België - Hudson Benelux

Hudson Benelux

Geverifieerd bedrijf

Charleroi, België

2 weken geleden

Geplaatst door:

Sophie Dubois

beBee Recruiter

Beschrijving

NeuVasQ Biotechnologies, a spin-off from the Université Libre de Bruxelles (ULB), is developing pharmaceuticals to sustain or restore neurovascular function, a novel mechanism to interfere with disease progression for the benefit of millions of patients affected by neurological disorders.

rmation

Position

Drive the discovery, optimization and early development of newly engineered proteins and antibodies that activate specific pathways associated with the function of the BBB
Leverage structural biology insights as well as known protein interactions to propose novel protein and antibody designs
Work with other scientists in the Discovery team to develop in vitro and cellbased assays to allow primary and secondary screens of protein and antibody libraries at highthroughput
Design, synthesize, and screen/evaluate protein and antibody libraries to identify and select the most promising constructs
Conduct comprehensive physicochemical and functional characterizations of selected proteins and antibodies and implement sequence optimization strategies to improve performance against target profiles and criteria
Collaborate with other scientists for the in vivo evaluation of selected proteins and antibodies in relevant disease models
Establish and oversee collaborations with CROs where relevant, e.g. to increase scale and/or throughput

Profile

Solid expertise in structural biology and protein chemistry, with a proven track record of protein and antibody engineering to generate novel therapeutics
Experience developing protein and antibody agonists that target membrane proteins and signalling pathways
Deep knowledge and experience with a range of protein engineering approaches, including rational design, screening and selection methods
Deep knowledge and experience with distinct antibody formats, including nanobodies
Knowledge of critical issues in drug discovery
Strong sense of practical execution, with focus on achieving company milestonesTeamwork experience, preferably in a biotech startup environment

Minimum qualifications

At least 5 years of proven industry experience in the discovery and engineering of both novel therapeutic protein and antibodies
A Ph.

D. degree, plus post-doctoral or similar experience, in biochemistry, structural biology, chemical engineering, molecular biology, chemistry, or similar fields.

Offer

The challenge and excitement of an expanding startup
Close collaboration with the founders and a great international team of experts in science
The possibility to boost your experience and career
You will join a highly motivated, international and dynamic team