Team Leader Protein Science - Gent, België - Panda International

Panda International

Geverifieerd bedrijf

Gent, België

1 dag geleden

Geplaatst door:

Sophie Dubois

beBee Recruiter

Beschrijving

Team Leader Protein Science:

Location

Ghent/Zwijnaarde, Belgium

Business Sector

Biotechnology

Job ref

22289

Published

1 day ago

Team Leader - Protein Sciences

For our client - an innovative biotech in Gent, Belgium that specializes in discovery targeting GPCR conformations - I am looking for motivated and experience scientist to lead their Protein Science team.

You will lead the team using your experience in protein science and structural analysis along with a strong understanding of molecular interactions between protein and small molecules or biologics. This position offers an exciting opportunity to make a significant impact on cutting-edge scientific initiatives.

Your responsibilities:

Design and implement workflows to purify and characterize soluble and membrane proteins expressed in mammalian, bacterial, and insect cells
Responsible for implementing protein purification and protein quality assessment using several biochemical/analytical techniques
Enable active and inactive state GPCR complex structures with in house identified compounds via cryoEM for structurebased drug design
Working closely with medicinal chemists and CADD to help advance structure based drug discovery, de novo antibody discovery team to generate ConfoBodies and molecular engineering to integrate the critical genetostructure activities
Stay informed with the latest advancements in cryoEM technologies and techniques, particularly in the context of GPCRs, and actively contribute to structural biology efforts
Maintain excellent relationships with current structural biology contract research organizations
Supervising and coaching a team of scientists and research associates
Leading the integrated discovery activities of projects as a core member of project teams: you will be expected to maintain focus and provide direction to the team members with clear project plans and defined timelines

Job requirements:

PhD or equivalent experience in a related field, with at least 5 years of experience in a company (Biotech or pharma)
Proficiency in protein engineering, cell culture, and protein expression in bacterial, insect, and mammalian systems is required
Prior experience with GPCR purification and structure determination
Experience in the entire single particle cryoEM workflow including protein vitrifications to determine high resolution structures of desired conformational states of integral membrane proteins
Experience in cryoEM data collection, data processing to generate electron density maps and model building and working knowledge of associated software tools such as CryoSPARC, ChimeraX, Phenix, Coot, or similar
Proficiency with Alphafold and/or other computational approaches in the design of proteins, structure prediction using homology modeling, molecular dynamic simulations and proteinligand docking
Experience with GPCR biophysical/biochemical characterization (such as fluorescence/analyticalSEC, thermostability, ITC, ligand binding, G protein activation) and screening (thermal shift, SPR, AF-MS, NMR)
Highly collaborative, selfmotivated, teamoriented individual
Strong leadership experience required
Ability to work in a fastpaced, highly integrated team environment where accuracy, accountability and timelines are essential
You are fluent in English and can communicate research results to the team and crossfunctional stakeholders across the company

Practicalities: