Investigative Toxicology Lab Lead - Braine-l'Alleud, België - UCB

UCB

Geverifieerd bedrijf

Braine-l'Alleud, België

2 weken geleden

Geplaatst door:

Sophie Dubois

beBee Recruiter

Beschrijving

Make your mark for patients
We are looking for a
Senior Scientist Investigative Toxicology to join us in our organization based in
Braine-l'Alleud, Belgium.

About the role:

You will collaborate with project leaders to implement scientific technologies with mínimal supervision to enhance productivity and efficiency within the Non-Clinical Safety function
You will develop and/or implement novel assays based on organonchip for in vitro toxicity/safety assessment
You will design and execute predictive _in vitro_ toxicity assays to support discovery and early development programs
You will coordinate the analysis, interpretation, reporting, and archiving of data acquired
You will be in charge of training of junior laboratory staff

The position is based in the UCB laboratories and offices at the Braine-l'Alleud campus

What you will do:

You will develop, optimize, and implement physiologically relevant organonchip _in vitro_ models, including providing technical expertise, design and execute qualification plans, and establish relevant endpoint assays to dissect the molecular mechanisms of toxicity
You will focus on understanding the impact of UCB compounds on target organs toxicities according to the target organ strategies
You will conduct _in vitro_ experiments to identify potential liabilities in preclinical drug development
You will design of experimental setup, sample organization and preparation, data processing and analysis, reporting of the results
You will ensure translation of strategy into handson lab work
You will coach team members and help them with experimental setups ensuring adequate reporting of data and results
You will guarantee proper experiment planning and execution, providing technical support when necessary
You will communicate effectively and provide regular updates to team meetings to achieve high transparency, quality and traceability
You will participate in the drafting of SOPs in order to be compliant with internal guidelines
You will ensure correct and accurate documentation during operations, recording all experimental data and test results accurately and in the specified format
You will establish, verify, validate and implement procedures and technical protocols
You will independently review the literature to generate hypotheses for experimental testing. Design and coordinate the execution, analysis, and interpretation of relevant experiments to test hypotheses
You will connect with CROs on outsourcing activities to optimize output regarding time, cost and quality
You will connect to the outside community via consortia, collaborations, joint projects, chaired sessions, contribution to conferences and publications
You will maintain current awareness of technology and theoretical development in the fields relevant to _in vitro_ toxicology

Ensure that activities are conducted in ethical and safe manner according to the UCB code of conduct.

For this position you'll need the following education, experience
and skills**:

You have a PhD with at least 2 years post-doc experience
You have demonstrated expertise in microphysiological systems/organonchip_ _approaches with particular focus on characterizing toxicopharmacological effect
You have experience in working with a variety of in vitro cell model systems including primary cultures and iPSCderived cells
You have a profound interest in the execution of laboratorybased activities
You have expertise in mammalian cell culture (primary, iPSC), imaging, molecular biology (RNA, DNA, protein) and biochemical endpoints (ELISA, MSD, qPCR, Capillary electrophoresisbased immunoassay, Western Blot)
You have some good interpersonal skills to communicate and maintain good working relationships within the team and with internal/external collaborators
You have the ability to work independently in the experimental design and execution, data analysis, data interpretation and communication
You have a high level of motivation, initiative, autonomy, flexibility with a resultoriented & problemsolving mindset
You have excellent organizational and record keeping skills, capable of independently managing multiple projects in a fastpaced environment
You have strong written communication skills for presenting and articulating experimental findings and conclusions to project teams and general audiences

Are you ready to 'go beyond' to create value and make your mark for patients? If this sounds like you, then we would love to hear from you

About us
UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are around 8,500 people in all four corners of the globe, inspired by patients and driven by science.

Why work for us?
At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture wh